The Neuroprotective Effects of SIRT1 on NMDA-Induced Excitotoxicity
Effects of RSV on NMDA-induced decrease in cell viability in primary neurons. (a) Pretreatment of RSV (10 μM, 25 μM, 50 μM, and 75 μM) improved cell viability compared with the NMDA treatment group (). (b) RSV (25 μM) significantly reversed NMDA-induced decrease in cell viability (), and Sirtinol (10 μM) inhibited the effect of RSV (). RSV: resveratrol; MK: MK-801. Each value represents the mean ± S.E.M. of six independent experiments. versus the control group, # versus the NMDA group, & versus the RSV + NMDA group.
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