Research Article
The Neuroprotective Effects of SIRT1 on NMDA-Induced Excitotoxicity
Figure 8
Effects of SIRT1 overexpression on p53 acetylation in NMDA-induced excitotoxicity of SH-SY5Y cell. WT-SIRT1 overexpression partially inhibited NMDA-stimulated p53 acetylation (), and DN-SIRT1 overexpression had no effect (). (a) Western blot probed with antibodies against p53 and Ace-p53. (b) Quantitative representations of Ace-p53 by bar graph. Each value represents the mean ± S.E.M. of three independent experiments. versus the control group, # versus the NMDA group.
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