Mechanisms Underlying the Essential Role of Mitochondrial Membrane Lipids in Yeast Chronological Aging

Figure 1

Processes that define the relative concentrations of different phospholipid classes in both membranes of yeast mitochondria. These processes are facilitated by proteins that reside in the IMM, IMS, OMM, and ER. Only proteins facilitating these processes in the IMM, IMS, and OMM are shown. A T bar denotes a CL-dependent inhibition of PA transfer from the OMM to the IMM. See text for more details. CDP-DAG: cytidine diphosphate-diacylglycerol; CL: cardiolipin; DAG: diacylglycerol; ER: endoplasmic reticulum; IMM: inner mitochondrial membrane; IMS: intermembrane space; MAM: mitochondria-associated membrane domain of the ER; MICOS: mitochondrial contact site protein complex; MLCL: monolysocardiolipin; OMM: outer mitochondrial membrane; PA: phosphatidic acid; PC: phosphatidylcholine; PG: phosphatidylglycerol; PGP: phosphatidylglycerol-phosphate; PI: phosphatidylinositol; PS: phosphatidylserine.