Cardiovascular Mitochondrial Dysfunction Induced by Cocaine: Biomarkers and Possible Beneficial Effects of Modulators of Oxidative Stress

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td class="align_left">Antioxidant <br/>compounds</td><td class="align_center">Mechanism of action</td><td class="align_center">References</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td class="align_left">MitoQ</td><td class="align_center">Inhibition of XO activity <br/>and protection of mitochondria <br/>membrane potential</td><td class="align_center">[<a href="/journals/omcl/2017/3034245/#B20">20</a>, <a href="/journals/omcl/2017/3034245/#B47">47</a>, <a href="/journals/omcl/2017/3034245/#B148">148</a>]</td></tr><tr><td class="align_left">Idebenone <br/>(short chain <br/>quinone)</td><td class="align_center">Transferring of electron in <br/>mitochondrial respiratory <br/>chain from cytoplasm to <br/>complex III (bypass deficiency <br/>in complex I)</td><td class="align_center">[<a href="/journals/omcl/2017/3034245/#B149">149</a>–<a href="/journals/omcl/2017/3034245/#B152">152</a>]</td></tr><tr><td class="align_left">Allopurinol</td><td class="align_center">Inhibition of XO activity <br/>and consequent rescue of in <br/>ATP production</td><td class="align_center">[<a href="/journals/omcl/2017/3034245/#B19">19</a>, <a href="/journals/omcl/2017/3034245/#B153">153</a>–<a href="/journals/omcl/2017/3034245/#B155">155</a>]</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Potential therapeutic use of selective antioxidant compounds for cocaine-induced mitochondrial impairment.

Oxidative Medicine and Cellular Longevity

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Table 2: Cardiovascular Mitochondrial Dysfunction Induced by Cocaine: Biomarkers and Possible Beneficial Effects of Modulators of Oxidative Stress 