Curcumin Reverses the Diazepam-Induced Cognitive Impairment by Modulation of Oxidative Stress and ERK 1/2/NF-κB Pathway in Brain

Figure 5

The effects of curcumin administration on memory in the Y-maze (a) and elevated plus maze (EPM) (b). The DZP group exhibited a significantly higher number of errors (a) in the Y-maze test as compared to the control group (). Conversely, curcumin administration significantly reversed the impairment of spontaneous alternation behavior (). Diazepam administration increased the transfer latency (b) both as compared to curcumin () and as compared to the control group () in L1. Each group consisted of 5 rats. Results are expressed as mean ± SEM. as compared with control/CUR + CMC; ^# as compared with DZP + CMC; as compared with control/CUR + CMC; and as compared with control/CUR + CMC.

(a)

(b)