Curcumin Reverses the Diazepam-Induced Cognitive Impairment by Modulation of Oxidative Stress and ERK 1/2/NF-κB Pathway in Brain

Figure 8

The effects of curcumin administration on the expression of NF-κB, pNF-κB, and iNOS in the brain. Expression of NF-κB, pNF-κB, and iNOS was analyzed by Western blot (WB). Image analysis of Western blot bands was done by densitometry, and results were normalized to GAPDH. WB images: 1–4 hippocampus, (1 = control, 2 = CUR + CMC, 3 = DZP + CMC, and 4 = DZP + CURC + CMC) and 5–8 frontal lobe (5 = control, 6 = CUR + CMC, 7 = DZP + CMC, and 8 = DZP + CURC + CMC); (). Each group consisted of 3 samples. as compared with control/CUR + CMC; as compared with control/CUR + CMC; as compared with control/CUR + CMC; ^## as compared with DZP + CMC; and ^### as compared with DZP + CMC.

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