Increased Mitochondrial Mass and Cytosolic Redox Imbalance in Hippocampal Astrocytes of a Mouse Model of Rett Syndrome: Subcellular Changes Revealed by Ratiometric Imaging of JC-1 and roGFP1 Fluorescence

<div>Sample images of a JC-1-labeled hippocampal astrocyte. Displayed are the individual raw images acquired by the two detection channels, representing JC-1 monomers and J-aggregates, respectively. The offline computed overlay image confirms the perfect alignment of the spectrally differing images. The calculated JC-1 ratio (red/green) represents the ΔΨm range of individual mitochondria and their morphological/functional heterogeneity.</div>

Oxidative Medicine and Cellular Longevity

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Figure 2: Increased Mitochondrial Mass and Cytosolic Redox Imbalance in Hippocampal Astrocytes of a Mouse Model of Rett Syndrome: Subcellular Changes Revealed by Ratiometric Imaging of JC-1 and roGFP1 Fluorescence 

Figure 2 | Increased Mitochondrial Mass and Cytosolic Redox Imbalance in Hippocampal Astrocytes of a Mouse Model of Rett Syndrome: Subcellular Changes Revealed by Ratiometric Imaging of JC-1 and roGFP1 Fluorescence 