Ameliorative Effect of Daidzein on Cisplatin-Induced Nephrotoxicity in Mice via Modulation of Inflammation, Oxidative Stress, and Cell Death

Figure 3

Effects of daidzein on cisplatin-induced cell death. Histological examination (a) demonstrated cisplatin-induced TUNEL staining (green) in the kidney and TUNEL staining was significantly attenuated with daidzein administration. Nuclei were stained with Hoechst 33342 (blue). (b) Caspase-3 activities were determined and daidzein attenuated cisplatin-induced caspase-3 activity. Results are mean ± SEM (/group). versus vehicle and ^# versus cisplatin.

(a)

(b)