Ameliorative Effect of Daidzein on Cisplatin-Induced Nephrotoxicity in Mice via Modulation of Inflammation, Oxidative Stress, and Cell Death

Figure 4

Effect of daidzein on cisplatin-induced oxidative/nitrative stress. (a) Quantitative measurement of HNE adducts and protein nitration by ELISA demonstrated cisplatin-induced lipid peroxidation and protein nitration. Daidzein attenuated both cisplatin-induced oxidative/nitrative stress markers. (b) Histological staining of protein nitration. A trend similar to quantitative protein nitration was observed. Results are mean ± SEM (/group). versus vehicle and ^# versus cisplatin.

(a)

(b)