Ameliorative Effect of Daidzein on Cisplatin-Induced Nephrotoxicity in Mice via Modulation of Inflammation, Oxidative Stress, and Cell Death

Figure 5

Effect of daidzein on cisplatin-induced changes in the ROS-generating enzyme NOX2 and antioxidant defense in mice. (a) Cisplatin induced the ROS-generating enzyme NOX2 mRNA as determined by real-time PCR, and daidzein attenuated cisplatin-reduced reduced glutathione reserve, glutathione peroxidase activity, and SOD activity. Daidzein administration restored those antioxidant defenses close to the control group. Results are mean ± SEM (/group). versus vehicle and ^# versus cisplatin.

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