Ameliorative Effect of Daidzein on Cisplatin-Induced Nephrotoxicity in Mice via Modulation of Inflammation, Oxidative Stress, and Cell Death

Figure 6

Effect of daidzein on cisplatin-induced CD11b-positive monocyte/macrophage in mice. Immunofluorescence examination revealed significant CD11b-positive cells (yellow) of the cisplatin-treated group. Nuclear staining (blue) was carried out using Hoechst 33342. In the cisplatin group, a zoom image of single cells was provided as an inset to demonstrate that staining covers surface staining and a larger area than nuclear staining. Daidzein treatment reduced the number of CD11b-positive cells. Either vehicle (Veh) or daidzein (daidz) control group does not have any CD11b-positive cells.