Ameliorative Effect of Daidzein on Cisplatin-Induced Nephrotoxicity in Mice via Modulation of Inflammation, Oxidative Stress, and Cell Death

Figure 7

Effect of daidzein on cisplatin-induced proinflammatory cytokines in mice. (a) Real-time PCR-based analyses of proinflammatory cytokines TNFα, IL-10, IL-18, and MCP-1 indicated a profound increase in cisplatin-treated mice. Daidzein treatment attenuated cisplatin-induced cytokine MRNA expression. Results are mean ± SEM (/group). versus vehicle and ^# versus cisplatin. (b) Western blot analyses of TNFα and control GAPDH.

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