Ameliorative Effect of Daidzein on Cisplatin-Induced Nephrotoxicity in Mice via Modulation of Inflammation, Oxidative Stress, and Cell Death

Figure 9

Schematic diagram of the protection mechanism of daidzein in cisplatin-induced kidney injury. EGCG inhibit cisplatin-induced ROS by attenuating ROS-generating enzymes and improving cisplatin-impaired antioxidant defense mechanisms in the renal tubular cells which caused cell death. Cell death also leads to proinflammatory response with cytokines and infiltrating leukocytes with the additional release of ROS. Daidzein attenuates cell death directly. Daidzein also neutralize cytokines and infiltrating leukocytes. Both antioxidant and anti-inflammatory effects leads to reduced cell death, thus protecting against cisplatin-induced kidney injury.