Antifatigue Effect of Luteolin-6-C-Neohesperidoside on Oxidative Stress Injury Induced by Forced Swimming of Rats through Modulation of Nrf2/ARE Signaling Pathways

Table 2

Effects of LN on serum biochemical parameters and glycogen storage after exhaustive swimming.

Group	Dose (mg/kg)	BUN (IU/L)	LDH (IU/L)	LA (mmol/L)	LG (mg/g)	MG (mg/g)	AST (U/L)	ALT (U/L)
NC	—	8.9 ± 0.3	128.5 ± 3.7	8.9 ± 0.4	23.4 ± 1.5	1.35 ± 0.17	121.23 ± 18.65	36.76 ± 4.76
MC	—	16.3 ± 1.5^##	256.8 ± 16.3^##	30.4 ± 1.0^###	7.9 ± 1.3^###	0.74 ± 0.09^##	335.66 ± 62.88^###	99.44 ± 31.34^###
AA100	100	11.7 ± 0.6	138.1 ± 12.1	12.5 ± 1.2	14.7 ± 0.4	1.16 ± 0.09	168.94 ± 21.37	47.32 ± 6.68
LN75	75	9.4 ± 0.7	139.2 ± 6.9	10.9 ± 1.6	16.0 ± 0.7	1.12 ± 0.15	137.56 ± 15.42	40.55 ± 11.07
LN50	50	10.2 ± 0.9	177.9 ± 18.3	11.3 ± 0.8	13.2 ± 0.4	1.05 ± 0.13	196.17 ± 35.29	50.27 ± 7.81
LN25	25	11.1 ± 0.7	201.5 ± 22.6	16.4 ± 1.1	10.8 ± 0.2	0.98 ± 0.07	224.95 ± 41.16	67.32 ± 14.65

Data are means ± SD (). ^## and ^### compared with NC (normal control group); , , and compared with MC (model control group). BUN: blood urea nitrogen; LDH: lactate dehydrogenase; LA: serum lactic acid; LG: liver glycogen; MG: skeletal muscle glycogen; AST: aspartate aminotransferase; ALT: alanine aminotransferase; AA100: positive control group (exhaustive swimming rats treated with ascorbic acid); LN75: LN high-dosage group (exhaustive swimming rats treated with LN at 75 mg/kg); LN50: LN medium-dosage group (exhaustive swimming rats treated with LN at 50 mg/kg); LN25: LN low-dosage group (exhaustive swimming rats treated with LN at 25 mg/kg).