HIV-1 Transactivator Protein Induces ZO-1 and Neprilysin Dysfunction in Brain Endothelial Cells via the Ras Signaling Pathway

Figure 5

Role of Ras signaling in HIV-1 Tat-induced changes in intracellular ROS levels. Exposure to HIV-1 Tat for 24 h significantly increased intracellular ROS levels in HBEC-5i cells. Pretreatment with 5 μmol/L FTS and then coexposure to HIV-1 Tat and FTS markedly attenuated HIV-1 Tat-induced intracellular ROS production. Results are shown as means ± standard error of the mean (). versus that in the control; ^### versus that in HIV-1 Tat.

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