Diosmin Attenuates Methotrexate-Induced Hepatic, Renal, and Cardiac Injury: A Biochemical and Histopathological Study in Mice

Figure 3

Histopathologic examination of liver tissue by H&E at ×400. CV: central vein; V: vacuolar degeneration; S: sinusoids. The arrow indicates necrosis and lymphocytic infiltrations. Groups are (a) normal liver tissue in the negative control group, (b) MTX group, (c) MTX + diosmin 50 mg/kg group, and (d) MTX + diosmin 100 mg/kg group.

(a)

(b)

(c)

(d)