Differential Susceptibility of Germ and Leydig Cells to Cadmium-Mediated Toxicity: Impact on Testis Structure, Adiponectin Levels, and Steroidogenesis
Table 2
Leydig cell absolute microstructural parameters obtained from the testis of control and exposed rats to four different Cd concentrations.
Parameters
Control
Cd1
Cd2
Cd3
Cd4
Nuclear diameter (μm)
6.4 ± 0.2
5.88 ± 0.3
5.6 ± 0.9
5.5 ± 0.3
5.2 ± 0.3
Nuclear volume (μm3)
146.2 ± 20.6
121.1 ± 19.4
113.2 ± 26.2
108.3 ± 10.7
101.1 ± 9.1
Cytoplasm volume (μm3)
500.1 ± 105.1
394.6 ± 135.9
306.4 ± 108.1
268.2 ± 98.6
201.0 ± 150.3
Cell volume (μm3)
646.3 ± 103.5
515.7 ± 149.9
419.6 ± 132.3
376.5 ± 105.4
302.1 ± 152.4
Cells per testis (×108)
7.6 ± 2.2
10.8 ± 5.9
6.1 ± 3.6
8.4 ± 4.4
12.2 ± 4.7
Cells per testis gram (×108)
6.1 ± 3.0
11.9 ± 6.7
7.0 ± 3.2
7.3 ± 3.5
13.4 ± 5.9
Nucleus/cytoplasm ratio
21.4 ± 1.2
23.98 ± 5.3
28.5 ± 10.8
28.4 ± 11.3
31.7 ± 12.4
Control (CT): 0.9% saline; Cd1: 0.67 mg Cd/kg; Cd2: 0.74 mg Cd/kg; Cd3: 0.86 mg Cd/kg; and Cd4: 1.1 mg Cd/kg. Data are expressed as mean and standard deviation (mean ± SD). Statistical difference ( versus CT).
