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Oxidative Medicine and Cellular Longevity
Volume 2017 (2017), Article ID 3494289, 8 pages
Review Article

FOXO Transcriptional Factors and Long-Term Living

1Beijing University of Chinese Medicine, Beisanhuan East Road, Beijing 100029, China
2Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, Pakistan
3Institute of Automation, Chinese Academy of Sciences, Beijing, China
4Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad, Pakistan
5Department of Pharmacy, University of Lahore, Lahore, Pakistan
6Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan

Correspondence should be addressed to Ghulam Murtaza; moc.liamg@653ragodmg and Jianxin Chen; nc.ude.mcub@xjc

Received 6 May 2017; Accepted 21 June 2017; Published 15 August 2017

Academic Editor: Jacek Kurzepa

Copyright © 2017 Ghulam Murtaza et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Figure 3. Confidence view of the protein networks of FOXO1, FOXO3, FOXO4 and FOXO6. Thick lines indicate stronger associations. Grey and green lines represent the protein-protein. SIRT1 - Sirtuin 1; AKT1 - v-akt murine thymoma viral oncogene homolog 1; AKT2 - v-akt murine thymoma viral oncogene homolog 2; AKT3 - v-akt murine thymoma viral oncogene homolog 3; BCL2L11 - BCL2-like 11; CDK2 - Cyclin-dependent kinase 2; CDKN1A - Cyclin-dependent kinase inhibitor 1A; CDKN1B - Cyclin-dependent kinase inhibitor 1B; CREBBP - CREB binding protein; CTNNB1 - Catenin (cadherin-associated protein), beta 1; FHL2 - Four and a half LIM domains 2; EP300 - E1A binding protein p300; GADD45A - Growth arrest and DNA-damage-inducible, alpha; IKBKB - Inhibitor of kappa light polypeptide gene enhancer in B-cells; INS – Insulin; MAPK8 - Mitogen-activated protein kinase 8; SGK1 - Serum/glucocorticoid regulated kinase 1 (526 aa); SGK2 - Serum/glucocorticoid regulated kinase 2; SGK3 - Serum/glucocorticoid regulated kinase family, member 3; SMAD2 - SMAD family member 2; SMAD3 - SMAD family member 3; SMAD4 - SMAD family member 4; STK4 - Serine/threonine kinase 4; PRKAA2 - Protein kinase, AMP-activated, alpha 2 catalytic subunit; YWHAZ - Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide and USP7 - Ubiquitin specific peptidase 7. Table 1. Protein-protein network stats. Figure 4. Organic layout algorithm of functionally grouped networks produced through ClueGO analysis to predict the potential targets of FOXO1, FOXO3, FOXO4 and FOXO6. Each group comprises of the most significant terms only. The overlapped groups indicates their functional likeness. Table 2. GO terms and their associated genes.

  1. Supplementary Material