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Oxidative Medicine and Cellular Longevity
Volume 2017 (2017), Article ID 3494867, 14 pages
https://doi.org/10.1155/2017/3494867
Review Article

Oxidative Stress in Patients Undergoing Peritoneal Dialysis: A Current Review of the Literature

1Division of Nephrology and Hypertension, 1st Department of Internal Medicine, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
2Clinic of Nephrology and Hypertension, Diabetes and Endocrinology, Otto-von-Guericke University Magdeburg, Magdeburg, Germany

Correspondence should be addressed to Vassilios Liakopoulos; rg.teneto@lupokail

Received 14 August 2017; Revised 15 November 2017; Accepted 11 December 2017; Published 27 December 2017

Academic Editor: Janusz Gebicki

Copyright © 2017 Vassilios Liakopoulos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Peritoneal dialysis (PD) patients manifest excessive oxidative stress (OS) compared to the general population and predialysis chronic kidney disease patients, mainly due to the composition of the PD solution (high-glucose content, low pH, elevated osmolality, increased lactate concentration and glucose degradation products). However, PD could be considered a more biocompatible form of dialysis compared to hemodialysis (HD), since several studies showed that the latter results in an excess accumulation of oxidative products and loss of antioxidants. OS in PD is tightly linked with chronic inflammation, atherogenesis, peritoneal fibrosis, and loss of residual renal function. Although exogenous supplementation of antioxidants, such as vitamins E and C, N-acetylcysteine, and carotenoids, in some cases showed potential beneficial effects in PD patients, relevant recommendations have not been yet adopted in everyday clinical practice.