Inhibition of Caveolae Contributes to Propofol Preconditioning-Suppressed Microvesicles Release and Cell Injury by Hypoxia-Reoxygenation

Figure 2

Effects of different concentrations of propofol on H/R-induced mitochondrial damage and apoptosis. (a) Different concentrations of propofol preconditioning ameliorated H/R-induced mitochondrial viability. (b) Different concentrations of propofol preconditioning enhanced the H/R-induced mitochondrial activity measured by intracellular ATP content. (c) Different concentrations of propofol preconditioning ameliorated H/R-induced decrease of mitochondrial membrane potential. (d) The effects of different concentrations of propofol preconditioning on H/R-induced mitochondrial membrane permeability. (e–j) Detecting the expression level of CAV-1, Bax, BCL2, cytochrome c, caspase 3, COX IV, and their gray scales calculated by ImageJ software. Mean ± SD are from 5 different experiments. refers to , refers to .

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