Fe-S Clusters Emerging as Targets of Therapeutic Drugs

Figure 3

Cluvenone-derivative MAD-28 destabilizes mitoNEET [2Fe-2S] cluster. (a) Picture of mitoNEET protein (grey) with a [2Fe-2S] cluster coordinated by 3 cysteines (not shown) and one histidine (His87, shown in grey). The coordinating bond is shown in orange. (b) The influence of MAD-28 (yellow) binding to mitoNEET. MAD-28 set up bonds with both Lys55 and His87 and weakens the bond between Iron and His87, thus destabilizing the cluster.

(a)

(b)