Prevention of Streptozotocin-Induced Diabetic Nephropathy by MG132: Possible Roles of Nrf2 and IκB

Figure 1

MG132 retained partial protection against diabetes-induced albuminuria despite deletion of the Nrf2 gene. UACR (a), kidney weight/tibia length (b), blood glucose (c), and body weight (d) were determined in all mice. Diabetes-induced pathological changes (fold) between wild-type and Nrf2-KO mice and the decreased percentages of these pathological changes with MG132 between WT and Nrf2-KO diabetic mice were compared (e). Data are presented as mean ± SD. versus WT/control or Nrf2-KO/control correspondingly; versus WT/DM or Nrf2-KO/DM correspondingly; versus wild-type mice.

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