Prevention of Streptozotocin-Induced Diabetic Nephropathy by MG132: Possible Roles of Nrf2 and IκB

Figure 5

Effects of MG132 on diabetes-induced renal inflammation were determined by detecting the expression of IL-6 (a) and NF-kB (b) with western blotting assay. Diabetes-induced inflammatory changes (fold) between wild-type and Nrf2-KO mice and the decreased percentages of these changes with MG132 between WT and Nrf2-KO diabetic mice were compared (c). Data are presented as mean ± SD. versus WT/control or Nrf2-KO/control correspondingly; versus WT/DM or Nrf2-KO/DM correspondingly; versus WT mice.

(a)

(b)

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