Prevention of Streptozotocin-Induced Diabetic Nephropathy by MG132: Possible Roles of Nrf2 and IκB

Figure 6

Possible mechanisms under which MG132 attenuates DN. 20S proteasome activity (a), Nrf2 expression at both mRNA (b) and protein levels (c), and Nrf2 downstream gene, NQO-1 mRNA (d) were examined in all mice. In addition, IkB-α protein level (e) was determined by western blotting assay. Data are presented as mean ± SD. versus WT/control or Nrf2-KO/control correspondingly; versus WT/DM or Nrf2-KO/DM correspondingly.

(a)

(b)

(c)

(d)

(e)