Lysosomes as Oxidative Targets for Cancer Therapy

Figure 1

Regulation of lysosomal membrane permeabilization (LMP). There are many factors that regulate lysosomal membrane permeabilization (LMP). These include increased levels of sphingosine, cathepsins, and ROS. The activation of caspase, Bax, and p53 and treatment with staurosporine, or lysosomotropic agents, also lead to LMP. This results in the release of ROS, cathepsins, and reactive iron from lysosomes.