Ischemic Retinopathies: Oxidative Stress and Inflammation

Figure 3

Scheme summarizing the risk factors of AMD, the link between oxidative stress and inflammatory factors involved in the pathogenesis of dry AMD and the current antioxidant/anti-inflammatory therapeutic trials and recommendations. CFH: complement factor H; CFB: complement factor B; C3: complement 3; APOE: apolipoprotein E; NADH: nicotinamide adenine dinucleotide H; SOD2: superoxide dismutase 2; ROS: reactive oxygen species; MCP1: monocyte chemotactic protein 1; CX3CL1: C-X3-C motif chemokine ligand 1; IL-1β: interleukine 1 beta; iNOS: inducible nitric oxide synthase; TNFα: tumor necrosis factor alpha; NRTI: nucleoside reverse transcriptase inhibitor; RPE: retinal pigment epithelium.