circRNA_0046367 Prevents Hepatoxicity of Lipid Peroxidation: An Inhibitory Role against Hepatic Steatosis
PPARα restoration improves hepatocellular steatosis by regulating genes associated with lipid metabolism. (a) PPARα restoration by circRNA_0046367 promotes the expression of CPT2 and ACBD3 at transcriptional level. (b), (c) Transcriptional activation of both CPT2 and ACBD3 results in their expressive upregulation (b) with statistical significance (c). (d), (e) Increased expression of lipometabolic genes leads to the reduction of TG level (d) and attenuation of hepatocellular steatosis (e) (200x), respectively. The presented results are expressed as means ± S.D. , .
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