Molecular Mechanisms Responsible for Increased Vulnerability of the Ageing Oocyte to Oxidative Damage

Figure 2

Cyclic propagation OS via lipid peroxidation impacts oocyte quality. Upon the induction of OS, ROS can instigate the peroxidation of lipids and the subsequent generation of highly electrophilic lipid aldehyde by-products such as 4-HNE. 4-HNE has the capacity to covalently modify and damage a wide array of proteins, including those essential for meiosis [174]. Additionally, adduction of mitochondrial SDHA impairs the ETC chain leading to electron leakage and the initiation of a positive feedback loop resulting in the generation of more ROS and lipid aldehydes [103].