Dihydropyridine Derivatives as Cell Growth Modulators In Vitro

Figure 6

(a) Proliferation modulation activity of DOXO (columns 0) and of DHP derivatives K-2-11 and IB-32 (10 μg/mL) alone and in the presence of DOXO on L929 cells (expressed as ³H-thymidine incorporation, in CPM, -axis). Control cells (Ctrl) without DOXO (0 μg/mL) are presented in the 1st bar of each column. First column (0): control cells treated with DOXO, without DHPs. Added DOXO concentrations were expressed as μg/mL: 0.1 μg/mL, 0.5 μg/mL, and 1 μg/mL. Results were expressed as mean values of counts per minute (CPM) ± SD. (b) Proliferation modulation activity of DOXO (columns 0) and of DHP derivatives K-2-11 and IB-32 (10 μg/mL) alone and in the presence of DOXO on HMEC cells (expressed as ³H-thymidine incorporation, in CPM, -axis). (c) Proliferation modulation activity of DOXO (columns 0) and of DHP derivatives K-2-11 and IB-32 (10 μg/mL) alone and in the presence of DOXO on HOS cells (expressed as ³H-thymidine incorporation, in CPM, -axis). (d) Proliferation modulation activity of DOXO (columns 0) and of DHP derivatives K-2-11 and IB-32 (10 μg/mL) alone and in the presence of DOXO on HeLa cells (expressed as ³H-thymidine incorporation, in CPM, -axis).

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