Dihydropyridine Derivatives as Cell Growth Modulators In Vitro

Table 1

Studied 1,4-dihydropyridine derivatives, their chemical structures, molecular weight () values, LD₅₀ values (on NIH 3T3, normal mice embryonal fibroblast cells), and antiradical activity (ARA) determined by DPPH assay. The untreated level of the DPPH radical is designated as 100%. Data are presented as mean ± SD.

Number	Compound	Chemical structures		mg/kg	ARA ± SD; %
Group I
(1)	Diludine		253.30	>2000 (>7.9 mmol/kg); (32,000 mg/kg, mice, ip)
Group II
(2)	AP-12		579.61	692	0
(3)	IB-32		649.57	520	0
(4)	A2-15		505.56	>2000; (>3.9 mmol/kg)	0
Group III
(5)	V-1-32		727.43	1706
(6)	IOS-10003		970.01	NA
(7)	IOS-10004		938.01	NA
(8)	V-1-41		721.32	>2000
(9)	K-2-11		925.91	1482
(10)	D-3-59-1		1012.05	1706
(11)	K2-71		953.98	( mmol/kg)
(12)	Z41-74 [14]		577.35	2425

NA: not applicable (the data are absent).