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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 4076348, 13 pages
Review Article

Involvement of Mitochondrial Disorders in Septic Cardiomyopathy

1Intensive Care Department, Université de Lille, Inserm, CHU Lille, U995, Lille Inflammation Research International Center (LIRIC), Lille, France
2Département de Physiologie, CHU Martinique, Faculté de Médecine, Université des Antilles, 97200 Fort de France, France
3Université de Lille, Inserm, U995, Lille Inflammation Research International Center (LIRIC), Lille, France

Correspondence should be addressed to Sebastien Preau; moc.liamg@uaerp.bes

Received 19 May 2017; Revised 11 September 2017; Accepted 28 September 2017; Published 22 October 2017

Academic Editor: Gregory Giamouzis

Copyright © 2017 Arthur Durand et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. It remains a leading cause of death worldwide, despite the development of various therapeutic strategies. Cardiac dysfunction, also referred to as septic cardiomyopathy, is a frequent and well-described complication of sepsis and associated with worse clinical outcomes. Recent research has increased our understanding of the role of mitochondrial dysfunction in the pathophysiology of septic cardiomyopathy. The purpose of this review is to present this evidence as a coherent whole and to highlight future research directions.