Involvement of Mitochondrial Disorders in Septic Cardiomyopathy

Figure 3

Altered cardiac mitochondrial morphology in lipopolysaccharide- (LPS-) treated mice. Representative, longitudinal electron microscopy micrographs of the left ventricle from control (a) and LPS-treated (b, c) mice. Six hours after LPS administration, cardiac mitochondria displayed abnormalities such as swelling, loss of cristae, and cleared matrix. Representative areas of mitochondrial clustering (arrow) and myofibrils (asterisk) are indicated. IFM: interfibrillar mitochondria are arranged along the myofibrils; SSM: subsarcolemmal mitochondria.

(a) Control

(b) LPS

(c) LPS