Sirt1 Protects Endothelial Cells against LPS-Induced Barrier Dysfunction

Figure 4

Role of Sirt1 and RAGE in microvascular hyperpermeability induced by LPS. Mice were pretreated with SRT1720 or saline via tail vein injection 2 h prior to LPS treatment. The mice in the LPS group were injected with 15 mg/kg LPS intraperitoneally, followed by carotid vein cannulation and exudation measurement 6 h later. Microvascular permeability was determined by the relative dextran density outside the vessels to that inside the vessels. . versus control, ^# versus wild type with LPS treatment.