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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 4120421, 13 pages
Clinical Study

Iron Supplementation Effects on Redox Status following Aseptic Skeletal Muscle Trauma in Adults and Children

1School of Physical Education and Sport Science, University of Thessaly, Trikala, Greece
2Institute for Research and Technology of Thessaly (I.RE.TE.TH), Trikala, Greece
3Center for Research and Technology Hellas (CERTH), Thessaloniki, Greece
4School of Physical Education and Sport Science, Democritus University of Thrace, Komotini, Greece
5School of Sports, Performing Arts and Leisure, University of Wolverhampton, Wolverhampton, UK

Correspondence should be addressed to Athanasios Z. Jamurtas; rg.htu.ep@trumaja

Received 27 September 2016; Accepted 24 November 2016; Published 22 January 2017

Academic Editor: Steven McAnulty

Copyright © 2017 Chariklia K. Deli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Exercise-induced skeletal muscle microtrauma is characterized by loss of muscle cell integrity, marked aseptic inflammatory response, and oxidative stress. We examined if iron supplementation would alter redox status after eccentric exercise. In a randomized, double blind crossover study, that was conducted in two cycles, healthy adults () and children () received daily either 37 mg of elemental iron or placebo for 3 weeks prior to and up to 72 h after an acute eccentric exercise bout. Blood was drawn at baseline, before exercise, and 72 h after exercise for the assessment of iron status, creatine kinase activity (CK), and redox status. Iron supplementation at rest increased iron concentration and transferrin saturation (). In adults, CK activity increased at 72 h after exercise, while no changes occurred in children. Iron supplementation increased TBARS at 72 h after exercise in both adults and children; no changes occurred under placebo condition. Eccentric exercise decreased bilirubin concentration at 72 h in all groups. Iron supplementation can alter redox responses after muscle-damaging exercise in both adults and children. This could be of great importance not only for healthy exercising individuals, but also in clinical conditions which are characterized by skeletal muscle injury and inflammation, yet iron supplementation is crucial for maintaining iron homeostasis. This study was registered at Identifier: NCT02374619.