Neuronal Damage Induced by Perinatal Asphyxia Is Attenuated by Postinjury Glutaredoxin-2 Administration

Figure 4

Grx2 and Trx1 prevent the characteristic astrogliosis that follows neonatal hypoxia/ischemia. (a) Representative immunostainings of GFAP in the CA1 area of the hippocampus. Insets show the morphological details of astrocytes. (b) Quantification of GFAP+ cells as number of positive cells by mm² was used as a measurement of the reactive gliosis response. Bars represent the mean + SEM of 4 rats per group. Two-way ANOVA test [condition (sham, carotid): , ; treatment (veh, Grx2, and Trx1): , ; and interaction: , ] followed by Tukey’s post hoc tests was employed to analyze the data. . Scale bars 10 μm.

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