Resveratrol Ameliorates Mitochondrial Elongation via Drp1/Parkin/PINK1 Signaling in Senescent-Like Cardiomyocytes

<div>Resveratrol reduced the resistance of elongated mitochondria to CCCP-induced depolarization in H9c2 cells. (a, c) Mitochondrial membrane potential was detected using confocal microscopy by JC-1 fluorescent dye staining. Images were captured by confocal microscopy to show the variations of red and green FL; white scale bar represented 40 <i>μ</i>m. The ratio of red/green FL was calculated by the fluorescence microplate assay. 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(b, d) Mitochondrial morphology was detected using confocal microscopy (upper panels) by immunostaining with a TOM20 antibody (red); objective magnification, 63x; white scale bar represents 20 <i>μ</i>m. Magnified photographs showed a detail view of the area indicated in the upper panels.</div>

Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Resveratrol Ameliorates Mitochondrial Elongation via Drp1/Parkin/PINK1 Signaling in Senescent-Like Cardiomyocytes 