Table of Contents Author Guidelines Submit a Manuscript
Oxidative Medicine and Cellular Longevity
Volume 2017 (2017), Article ID 4176518, 9 pages
https://doi.org/10.1155/2017/4176518
Research Article

Biotransformation of Dioscorea nipponica by Rat Intestinal Microflora and Cardioprotective Effects of Diosgenin

1Department of Pharmaceutical Science, Leshan Vocational & Technical College, Leshan 614000, China
2School of Chinese Medicine, Hong Kong Baptist University, Hong Kong Special Administrative Region, China
3Sichuan Academy of Chinese Medicine Sciences, Chengdu 610041, China
4School of Pharmaceutical Science, Guangzhou Medical University, Guangzhou 511436, China
5Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, China
6Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen 518057, China
7Institute of Research and Continuing Education (Shenzhen), Hong Kong Baptist University, Shenzhen 518057, China

Correspondence should be addressed to Lin Zhu and Tao Yi

Received 9 April 2017; Revised 18 July 2017; Accepted 24 July 2017; Published 20 September 2017

Academic Editor: Cristiana Caliceti

Copyright © 2017 Jia-Fu Feng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. H. Yang, Y. Wang, Y. X. Zeng et al., “Rapid health transition in China, 1990–2010: findings from the global burden of disease study 2010,” The Lancet, vol. 381, no. 9882, pp. 1987–2015, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. J. G. Long, M. L. Gao, Y. Kong et al., “Cardioprotective effect of total paeony glycosides against isoprenaline-induced myocardial ischemia in rats,” Phytomedicine, vol. 19, no. 8-9, pp. 672–676, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. F. Song, H. Li, J. Y. Sun, and S. W. Wang, “Protective effects of cinnamic acid and cinnamic aldehyde on isoproterenol-induced acute myocardial ischemia in rats,” Journal of Ethnopharmacology, vol. 150, no. 1, pp. 125–130, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. Y. N. Tang, X. C. He, Q. L. Chen et al., “A mixed microscopic method for differentiating seven species of “Bixie”-related Chinese Materia Medica,” Microscopy Research and Technique, vol. 77, no. 1, pp. 57–70, 2014. View at Publisher · View at Google Scholar · View at Scopus
  5. T. Yi, L. L. Fan, H. L. Chen et al., “Comparative analysis of diosgenin in Dioscorea species and related medicinal plants by UPLC-DAD-MS,” BMC Biochemistry, vol. 15, no. 1, p. 19, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. Y. N. Tang, T. Yi, H. M. Chen, Z. Z. Zhao, and H. B. Chen, “Quantitative comparison of multiple components in Dioscorea nipponica and D. panthaica by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry,” Phytochemical Analysis, vol. 24, no. 4, pp. 413–422, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. Y. N. Tang, X. C. He, M. Ye et al., “Cardioprotective effect of total saponins from three medicinal species of Dioscorea against isoprenaline-induced myocardial ischemia,” Journal of Ethnopharmacology, vol. 175, pp. 451–455, 2015. View at Publisher · View at Google Scholar · View at Scopus
  8. Y. N. Tang, Y. X. Pang, X. C. He et al., “UPLC-QTOF-MS identification of metabolites in rat biosamples after oral administration of Dioscorea saponins: a comparative study,” Journal of Ethnopharmacology, vol. 165, pp. 127–140, 2015. View at Publisher · View at Google Scholar · View at Scopus
  9. H. R. Vasanthi, N. ShriShriMal, and D. K. Das, “Phytochemicals from plants to combat cardiovascular disease,” Current Medicinal Chemistry, vol. 19, no. 14, pp. 2242–2251, 2012. View at Publisher · View at Google Scholar
  10. H. R. Vasanthi, S. Mukherjee, D. Ray, I. Lekli, and D. K. Das, “Protective role of air potato (Dioscorea bulbifera) of yam family in myocardial ischemic reperfusion injury,” Food & Function, vol. 1, no. 3, pp. 278–283, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. J. Y. Wan, P. Liu, H. Y. Wang et al., “Biotransformation and metabolic profile of American ginseng saponins with human intestinal microflora by liquid chromatography quadrupole time-of-flight mass spectrometry,” Journal of Chromatography A, vol. 1286, pp. 83–92, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. H. Y. Wang, H. Y. Hua, X. Y. Liu, J. H. Liu, and B. Y. Yu, “In vitro biotransformation of red ginseng extract by human intestinal microflora: metabolites identification and metabolic profile elucidation using LC-Q-TOF/MS,” Journal of Pharmaceutical and Biomedical Analysis, vol. 98, pp. 296–306, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. C. Kishimoto, H. Takada, H. Kawamata, M. Umatake, and H. Ochiai, “Immunoglobulin treatment prevents congestive heart failure in murine encephalomyocarditis viral myocarditis associated with reduction of inflammatory cytokines,” Journal of Pharmacology and Experimental Therapeutics, vol. 299, no. 2, pp. 645–651, 2001. View at Google Scholar
  14. G. Saravanan, P. Ponmurugan, M. Sathiyavathi, S. Vadivukkarasi, and S. Sengottuvelu, “Cardioprotective activity of Amaranthus viridis Linn: effect on serum marker enzymes, cardiac troponin and antioxidant system in experimental myocardial infarcted rats,” International Journal of Cardiology, vol. 165, no. 3, pp. 494–498, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. G. Szűcs, Z. Murlasits, S. Török et al., “Cardioprotection by farnesol: role of the mevalonate pathway,” Cardiovascular Drugs and Therapy, vol. 27, no. 4, pp. 269–277, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Himmelsbach, W. Buchberger, and E. Reingruber, “Determination of polymer additives by liquid chromatography coupled with mass spectrometry. A comparison of atmospheric pressure photoionization (APPI), atmospheric pressure chemical ionization (APCI), and electrospray ionization (ESI),” Polymer Degradation and Stability, vol. 94, no. 8, pp. 1213–1219, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. T. Ghislain, P. Faure, and R. Michels, “Detection and monitoring of PAH and Oxy-PAHs by high resolution mass spectrometry: comparison of ESI, APCI and APPI source detection,” Journal of the American Society for Mass Spectrometry, vol. 23, no. 3, pp. 530–536, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. L. C. Short, K. A. Hanold, S. S. Cai, and J. A. Syage, “Electrospray ionization/atmospheric pressure photoionization multimode source for low-flow liquid chromatography/mass spectrometric analysis,” Rapid Communications in Mass Spectrometry, vol. 21, no. 10, pp. 1561–1566, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. D. Cokkinos, C. Pantos, G. Heusch, and H. Taegtmeyer, Myocardial Ischemia Basic Concepts, in: Myocardial Ischemia: From Mechanisms to Therapeutic Potentials, Springer Science + Business Media, Inc, Boston, USA, 2006.
  20. D. Zhao, J. Yang, and L. Yang, “Insights for oxidative stress and mTOR signaling in myocardial ischemia/reperfusion injury under diabetes,” Oxidative Medicine and Cellular Longevity, vol. 2017, Article ID 6437467, 12 pages, 2017. View at Publisher · View at Google Scholar
  21. G. A. Kurian, R. Rajagopal, S. Vedantham, and M. Rajesh, “The role of oxidative stress in myocardial ischemia and reperfusion injury and remodeling: revisited,” Oxidative Medicine and Cellular Longevity, vol. 2016, Article ID 1656450, 14 pages, 2016. View at Publisher · View at Google Scholar · View at Scopus
  22. J. W. Walters, D. Amos, K. Ray, and N. Santanam, “Mitochondrial redox status as a target for cardiovascular disease,” Current Opinion in Pharmacology, vol. 27, pp. 50–55, 2016. View at Publisher · View at Google Scholar · View at Scopus
  23. K. Schwarz, N. Siddiqi, S. Singh, C. J. Neil, D. K. Dawson, and M. P. Frenneaux, “The breathing heart—mitochondrial respiratory chain dysfunction in cardiac disease,” International Journal of Cardiology, vol. 171, no. 2, pp. 134–143, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Noori, “An overview of oxidative stress and antioxidant defensive system,” Scientific Reports, vol. 1, p. 413, 2012. View at Publisher · View at Google Scholar
  25. X. R. Guan, L. Zhu, Z. G. Xiao, Y. L. Zhang, H. B. Chen, and T. Yi, “Bioactivity, toxicity and detoxification assessment of Dioscorea bulbifera L.: a comprehensive review,” Phytochemistry Reviews, vol. 16, no. 3, pp. 573–601, 2017. View at Publisher · View at Google Scholar
  26. K. Y. Ning, Y. K. Li, H. L. Gao, and L. D. Li, “Therapeutic effects of methyl protodioscin for myocardial infarction in rats,” Traditional Chinese Drug Research & Clinical Pharmacology, vol. 19, no. 1, pp. 1–3, 2008. View at Google Scholar
  27. L. F. Wang, Y. Q. Zhao, W. Z. Gao, J. S. Lou, and Y. Kang, “Dioscorea saponins increased antioxidative ability of myocardium after ischemia-perfusion injury in rat,” Pharmacology and Clinics of Chinese Materia Medica, vol. 25, no. 5, pp. 44–46, 2009. View at Google Scholar
  28. T. J. Wang, R. C. Choi, J. Li et al., “Trillin, a steroidal saponin isolated from the rhizomes of Dioscorea nipponica, exerts protective effects against hyperlipidemia and oxidative stress,” Journal of Ethnopharmacology, vol. 139, no. 1, pp. 214–220, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. E. Csepanyi, A. Czompa, D. Haines et al., “Cardiovascular effects of low versus high-dose beta-carotene in a rat model,” Pharmacological Research, vol. 100, pp. 148–156, 2015. View at Publisher · View at Google Scholar · View at Scopus