Pharmacological Basis for Use of Armillaria mellea Polysaccharides in Alzheimer’s Disease: Antiapoptosis and Antioxidation
Table 2
The effects of AMPSc on oxidative statues in serum or hypothalamus in AD mice.
CTRL
CTRL + AMPSc (mg/kg)
AlCl3 + D-gal
AlCl3 + D-gal + AMPSc (mg/kg)
100
25
100
Serum
SOD (U/mL)
98.6 ± 7.4
117.0 ± 5.7#
75.9 ± 3.9#
110.3 ± 5.3
111.5 ± 9.0
GSH-Px (U/mL)
249.8 ± 13.1
251.3 ± 5.7
213.4 ± 10.5##
254.4 ± 9.0
290.9 ± 16.0
Hypothalamus
SOD (U/mgprot)
44.4 ± 2.1
55.9 ± 4.6#
30.1 ± 2.6##
47.0 ± 4.8
66.1 ± 6.4
GSH-Px (U/mL)
326.1 ± 13.9
385.0 ± 27.2#
282.3 ± 16.4#
405.7 ± 31.1
501.4 ± 15.2
ROS (FI/mgprot)
23087.4 ± 1905.5
15564.8 ± 3030.9#
34418.8 ± 3986.2#
14104.1 ± 1260.5
17877.6 ± 2713.4
Treatment with AMPSc and the levels of SOD, GSH-Px, and ROS in serum and/or hypothalamus were detected via ELISA method. Data are expressed as mean ± S.E.M. (). # and ## versus normal mice (CTRL); and versus AD mice.