TBHQ Alleviated Endoplasmic Reticulum Stress-Apoptosis and Oxidative Stress by PERK-Nrf2 Crosstalk in Methamphetamine-Induced Chronic Pulmonary Toxicity

Figure 1

Effect of TBHQ on MA-induced pulmonary vascular remodeling. (a) Hypertrophy of pulmonary vessel wall by H&E staining (Olympus BX 51, Japan, ×400); (b) the muscularization of pulmonary arteries by EVG staining; (c) the percentage of medial wall thickness in different groups (Olympus BX 51, Japan, ×400); (d) muscularization degree of pulmonary arteries in different groups. The changes of pulmonary arteries were marked by black arrows. Compared with the control group, in MA group, the lumen was significantly narrowed and the wall of pulmonary arteries was markedly thickened, which were attenuated by TBHQ. Values are expressed as mean ± SD (). , , compared with the control group; , compared with the MA group. MA: methamphetamine; THBQ: tertiary butylhydroquinone.

(a)

(b)

(c)

(d)