Pentaerythritol Tetranitrate In Vivo Treatment Improves Oxidative Stress and Vascular Dysfunction by Suppression of Endothelin-1 Signaling in Monocrotaline-Induced Pulmonary Hypertension

Figure 3

Effects of PETN therapy on heart/body and lung/body weight ratio, pulmonary artery dilation, and pulmonary arterial pressure in monocrotaline-treated rats (MCT40, 4 weeks). (a) Chemical structure of PETN. (b) Lung/body and (c) heart/body weight ratio were determined. (d) Pulmonary artery dilation was qualitatively envisaged by photographic images. (e) Echocardiography was used to measure pulmonary arterial pressure. The data are mean ± SEM of 4 (b, c) and 3-4 (d, e) animals per group versus control and versus MCT.

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