Activation of the Nrf2-Keap 1 Pathway in Short-Term Iodide Excess in Thyroid in Rats

Figure 4

Effect of the iodide intake (NI, 10 HI, and 100 HI) on the changes of immunofluorescence staining on Days 7, 14, and 28. (a) In the NI group, Nrf2 (red) was localized in the cytoplasm on Days 7, 14, and 28. In the 10 HI group, the positive staining of Nrf2 can be observed in both the nucleus and the cytoplasm. Moreover, in the 100 HI group, a stronger positive staining of Nrf2 can be detected in the nucleus on Days 7, 14, and 28; the nucleus was dyed with Hoechst (blue). (b) Srx (red) positive staining was located in the cytoplasm; the nucleus was dyed with Hoechst (blue). Scale bar: 20 μm.

(a)

(b)