Activation of the Nrf2-Keap 1 Pathway in Short-Term Iodide Excess in Thyroid in Rats

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td class="align_left" rowspan="2">Group</td><td class="align_center" colspan="3">Iodine content in the thyroid glands (<i>μ</i>g/100 mg)</td></tr><tr class="thead"><td class="align_center">Day 7</td><td class="align_center">Day 14</td><td class="align_center">Day 28</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td class="align_left">NI</td><td class="align_center">62.19 ± 5.94</td><td class="align_center">60.12 ± 8.13</td><td class="align_center">63.37 ± 9.08</td></tr><tr><td class="align_left">10 HI</td><td class="align_center">121.25 ± 10.48</td><td class="align_center">126.45 ± 8.93</td><td class="align_center">152.33 ± 10.77</td></tr><tr><td class="align_left">100 HI</td><td class="align_center">133.53 ± 8.61<svg height="10.0793pt" id="M27" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -10.0295 6.44358 10.0793" width="6.44358pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M499 152C501 180 492 209 480 228C432 233 403 235 357 256C403 278 432 279 480 284C492 303 504 328 499 359C477 375 447 382 424 380C396 342 380 317 338 288C342 339 356 364 376 408C366 429 350 451 320 463C295 451 274 429 265 408C284 364 297 339 301 288C259 317 244 341 216 380C193 382 166 379 141 359C139 332 148 303 160 284C208 279 237 277 283 256C237 234 208 233 160 228C148 209 136 184 141 152C163 137 193 130 216 132C244 170 260 195 302 224C298 173 284 148 265 104C274 83 290 61 320 49C345 61 366 83 376 104C356 148 343 173 339 224C381 195 396 171 424 132C447 130 474 133 499 152Z" id="g14-43"></path><glyph.data ascent="3452" descent="-2858" horiz-adv-x="640" vert-adv-y="640"></glyph.data></g></svg></td><td class="align_center">136.36 ± 9.64<svg height="10.0793pt" id="M28" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -10.0295 6.44358 10.0793" width="6.44358pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M499 152C501 180 492 209 480 228C432 233 403 235 357 256C403 278 432 279 480 284C492 303 504 328 499 359C477 375 447 382 424 380C396 342 380 317 338 288C342 339 356 364 376 408C366 429 350 451 320 463C295 451 274 429 265 408C284 364 297 339 301 288C259 317 244 341 216 380C193 382 166 379 141 359C139 332 148 303 160 284C208 279 237 277 283 256C237 234 208 233 160 228C148 209 136 184 141 152C163 137 193 130 216 132C244 170 260 195 302 224C298 173 284 148 265 104C274 83 290 61 320 49C345 61 366 83 376 104C356 148 343 173 339 224C381 195 396 171 424 132C447 130 474 133 499 152Z" id="g14-43"></path><glyph.data ascent="3452" descent="-2858" horiz-adv-x="640" vert-adv-y="640"></glyph.data></g></svg></td><td class="align_center">178.45 ± 8.74<svg height="10.0793pt" id="M29" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -10.0295 6.44358 10.0793" width="6.44358pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M499 152C501 180 492 209 480 228C432 233 403 235 357 256C403 278 432 279 480 284C492 303 504 328 499 359C477 375 447 382 424 380C396 342 380 317 338 288C342 339 356 364 376 408C366 429 350 451 320 463C295 451 274 429 265 408C284 364 297 339 301 288C259 317 244 341 216 380C193 382 166 379 141 359C139 332 148 303 160 284C208 279 237 277 283 256C237 234 208 233 160 228C148 209 136 184 141 152C163 137 193 130 216 132C244 170 260 195 302 224C298 173 284 148 265 104C274 83 290 61 320 49C345 61 366 83 376 104C356 148 343 173 339 224C381 195 396 171 424 132C447 130 474 133 499 152Z" id="g14-43"></path><glyph.data ascent="3452" descent="-2858" horiz-adv-x="640" vert-adv-y="640"></glyph.data></g></svg></td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><svg height="10.0793pt" id="M30" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -10.0295 6.44358 10.0793" width="6.44358pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M499 152C501 180 492 209 480 228C432 233 403 235 357 256C403 278 432 279 480 284C492 303 504 328 499 359C477 375 447 382 424 380C396 342 380 317 338 288C342 339 356 364 376 408C366 429 350 451 320 463C295 451 274 429 265 408C284 364 297 339 301 288C259 317 244 341 216 380C193 382 166 379 141 359C139 332 148 303 160 284C208 279 237 277 283 256C237 234 208 233 160 228C148 209 136 184 141 152C163 137 193 130 216 132C244 170 260 195 302 224C298 173 284 148 265 104C274 83 290 61 320 49C345 61 366 83 376 104C356 148 343 173 339 224C381 195 396 171 424 132C447 130 474 133 499 152Z" id="g14-43"></path><glyph.data ascent="3452" descent="-2858" horiz-adv-x="640" vert-adv-y="640"></glyph.data></g></svg>Compared with NI group (<svg height="11.7782pt" id="M31" style="vertical-align:-3.42938pt" version="1.1" viewbox="-0.0498162 -8.34882 44.5261 11.7782" width="44.5261pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M570 304C570 398 525 448 414 448C385 448 343 445 312 434L329 511L321 518C297 504 262 482 244 460L233 411C195 397 159 381 128 358L135 332C160 347 189 360 224 373L111 -147C97 -210 84 -218 17 -231L13 -257L254 -247L259 -218L233 -216C183 -212 177 -202 189 -142L218 -1C238 -10 266 -12 283 -12C351 3 429 48 483 105C543 168 570 242 570 304ZM482 289C482 161 380 33 304 33C278 33 248 51 233 69L303 396C326 400 352 403 369 403C428 403 482 380 482 289Z" id="g113-113"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="593" vert-adv-y="593"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,11.342,0)"><path d="M512 -3V55L134 254V256L512 456V514L75 281V230L512 -3Z" id="g117-91"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="587" vert-adv-y="587"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,22.605,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z" id="g113-49"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,28.845,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z" id="g113-47"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="228" vert-adv-y="228"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,31.809,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z" id="g113-49"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,38.049,0)"><path d="M153 550H386L412 615L406 623H120L82 318C104 327 142 338 184 338C294 338 347 275 347 187C347 112 305 39 221 39C160 39 119 71 97 89C88 97 80 96 71 90C59 80 50 67 49 57C48 45 52 36 66 23C80 9 123 -12 169 -12C221 -11 288 15 342 59C403 109 431 165 431 225C431 308 366 395 238 395C212 395 165 379 127 364L153 550Z" id="g113-54"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g></svg>).<br/></td></tr></table>

Changes of iodine content in the thyroid glands (<i>μ</i>g/100 mg) of Wistar rats following the intake of NI, 10 HI, and 100 HI on Days 7, 14, and 28 (<svg height="8.8423pt" id="M26" style="vertical-align:-0.2064009pt" version="1.1" viewbox="-0.0498162 -8.6359 32.2343 8.8423" width="32.2343pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M822 650H589L583 622C660 617 677 607 674 561C672 534 664 481 647 390L600 137H596L273 650H126L120 622C176 620 194 615 207 594C221 571 225 557 214 504L161 257C141 166 129 112 121 85C108 42 83 30 29 28L23 0H260L266 28C193 33 173 42 176 89C178 122 186 172 202 255L256 527H259L583 -8H612L690 390C708 481 720 535 728 558C744 603 756 619 816 622L822 650Z" id="g113-79"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="839" vert-adv-y="839"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,14.542,0)"><path d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z" id="g117-34"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="587" vert-adv-y="587"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,25.805,0)"><path d="M137 343C167 482 260 545 321 574C357 591 397 603 429 609L423 641C382 634 335 622 295 608C189 570 37 457 37 238C37 84 125 -12 242 -12C362 -12 447 89 447 209C447 311 374 393 267 393C247 393 226 386 204 376L137 343ZM227 337C318 337 361 256 361 173C361 105 336 22 258 22C176 22 126 120 126 240C126 266 127 291 132 310C155 323 189 337 227 337Z" id="g113-55"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g></svg> for each group). All data is presented as the mean ± SD.

Oxidative Medicine and Cellular Longevity

tab2

Table 2

Table 2: Activation of the Nrf2-Keap 1 Pathway in Short-Term Iodide Excess in Thyroid in Rats 