SIRT1 Activation by Resveratrol Alleviates Cardiac Dysfunction via Mitochondrial Regulation in Diabetic Cardiomyopathy Mice

Figure 1

Resveratrol alleviated cardiac dysfunction in DCM mouse heart. (a) Increased heart weight/tibia length in STZ-induced DCM mice (). (b) Increased ventricle/body weight in DCM mice as compared with Con mice (). (c) Elevated expression of myocardial hypertrophy markers of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in DCM mouse heart (). (d) Impaired cardiac function in diabetic hearts (), while resveratrol treatment significantly reversed these changes in DCM mice (^#). (e) DCM mouse hearts displayed structural changes and fibrogenesis, and resveratrol markedly alleviated these changes. (f) SIRT1 was markedly downregulated in DCM mouse myocardium (), while resveratrol enhanced SIRT1 expression in DCM + RES mice (^#). versus Con; ^# versus DCM.

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