Reperfusion Therapy with Rapamycin Attenuates Myocardial Infarction through Activation of AKT and ERK

Figure 2

Rapamycin at the onset of reperfusion reduces infarct size. (a) Infarct size of C57 mouse hearts following 30 minutes of ischemia and 24 hours of reperfusion with and without Rapamycin treatment as percentage of risk area. After TTC and Phthalo blue staining, the blue area represents the remote area, the area at risk is stained red, and the infarcted myocardium is stained white. (b) Risk area as percentage of the overall tissue section. (c) Fractional shortening (%) as measured via echocardiography. (d) Ejection fraction (%). (e) Heart rate (BPM).

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