Reperfusion Therapy with Rapamycin Attenuates Myocardial Infarction through Activation of AKT and ERK

Figure 6

Effect of ERK inhibition on the infarct sparing effects of Rapamycin. (a) Whole tissue TTC and Phthalo blue staining of C57 mouse hearts following 30 minutes of ischemia and 24 hours of reperfusion with Rapamycin and/or PD98059. (b) Infarct size as a percentage of risk area. (c) Risk area as percent of LV. (d) Fractional shortening (%) as measured by echocardiography. (e) Ejection fraction (%). (f) Heart rate (BPM).

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