Rutin as a Mediator of Lipid Metabolism and Cellular Signaling Pathways Interactions in Fibroblasts Altered by UVA and UVB Radiation

Figure 5

The level of Nrf2 (a) and phospho-Nrf2 (b), its main target, HO-1 (c), its inhibitors (Bach1 (d), Keap1 (e)), and activators (p21, p62, KAP1, ERK1/2, and p38 (f–j)) in fibroblasts after exposure to UVA [20 J/cm²], UVB radiation [200 mJ/cm²], and rutin [25 μM] treatment and pretreatment, expressed as a percentage of the control cells value. Mean values ± SD of five independent experiments are presented. Statistically significant differences versus control group, . Statistically significant differences versus group without rutin, . Statistically significant differences versus group without rutin pretreatment, .