Parental High-Fat Diet Promotes Inflammatory and Senescence-Related Changes in Prostate

Figure 1

Chronic high-fat diet (HFD) feeding induces insulin resistance and prostatic enlargement. (a) Schematic diagram illustrating the experimental design. (b) Effect of chronic HFD feeding on the body weight of male and female rats (parents). (c) HFD feeding led to significant increase in the adiposity index in HFD-fed male rats as compared to age-matched NPD-fed control rats. (d) Effect of chronic HFD feeding on the ventral prostate (VP) weight. (e) Effect of chronic HFD feeding on the glucose tolerance in male rats. (f) Area under curve (AUC) of plasma glucose concentration and time curve (e). (g) The HFD-fed females were glucose intolerant. The glucose tolerance test was performed one week prior to keeping them for mating. (h) AUC of plasma glucose concentration and time curve (g). (i) No difference in the litter size and average gestation time was observed between HFD-fed and NPD-fed dams. (j and k) The plasma glucose and insulin levels were significantly higher in the HFD-fed females during gestation as well as lactation. The plasma glucose and insulin levels were determined one week after the males were separated and one week after the delivery of pups. All the values are shown as mean ± SEM. versus indicated group.

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