Research Article
Paricalcitol Pretreatment Attenuates Renal Ischemia-Reperfusion Injury via Prostaglandin E2 Receptor EP4 Pathway
Figure 7
Paricalcitol improved renal function and tubular necrosis via an EP4-dependent pathway in mice kidney with IR injury. (a) Paricalcitol improved serum creatinine levels at day 1 after IR injury, and AH-23848 cotreatment blunted the improvement of serum creatinine level in paricalcitol-treated mice with IR injury. (b) The representative stain of hematoxylin and eosin showed a decreased tubular necrosis in the paricalcitol-treated renal IR injury compared with renal IR injury alone. AH-23848 cotreatment with paricalcitol offset the protective effect on tubular necrosis. Original magnification ×200. versus sham group, versus IR group, and versus IR + Pari group; = 6–8 for each group. Bar = 50 μm.
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