Paricalcitol Pretreatment Attenuates Renal Ischemia-Reperfusion Injury via Prostaglandin E₂ Receptor EP4 Pathway

Figure 8

Paricalcitol enhanced Akt phosphorylation and inhibited p65 NF-κB phosphorylation via an EP4-dependent pathway in mice kidney with IR injury. (a) Paricalcitol further enhanced Akt phosphorylation in renal IR injury, but cotreatment with paricalcitol and AH-23848 significantly suppressed this effect. (b) p65 NF-κB phosphorylation was increased in mice kidney with IR injury, and paricalcitol significantly prevented its phosphorylation. This inhibitory effect of paricalcitol was offset by cotreatment with AH-23848. versus sham group, versus IR group, and versus IR + Pari group; = 6–8 for each group.

(a)

(b)