Paricalcitol Pretreatment Attenuates Renal Ischemia-Reperfusion Injury via Prostaglandin E₂ Receptor EP4 Pathway

Figure 9

Paricalcitol attenuated oxidative stress via an EP4-dependent pathway in mice kidney with IR injury. (a) IR exposure significantly increased malondialdehyde (MDA) levels and paricalcitol pretreatment significantly alleviated oxidative stress. This protective effect of paricalcitol in renal IR injury was offset by cotreatment of AH-23848. (b) The expression of the superoxide dismutase (SOD) 1 increased in paricalcitol-treated mice kidney with IR injury compared with mice kidney with IR injury alone. This antioxidative effect of paricalcitol was offset by cotreatment with AH-23848. versus sham group, versus IR group, and versus IR + Pari group; = 6–8 for each group.

(a)

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